Royal Air Force Typhoon fighter aircraft have operated alongside French warplanes in a combined operation on an underground arms cache in Syrian territory used by the IS group, as stated by the British defence ministry.
The site, located using reconnaissance, was assessed as storing arms and explosives, the statement said, and was situated in mountainous terrain just north of the historic site of Palmyra in Syria's central region.
"Our fighter planes employed laser-guided Paveway IV weapons to target a several access tunnels down to the depot... preliminary assessments indicate the strike was effective," the ministry announced.
There was no indication of any harm to civilians in the attack late on Saturday and every plane involved made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
The Islamic State group - also known as Daesh - established extremist governance over parts of Syria and Iraq until 2019.
"This strike underscores our UK leadership, and determination to stand shoulder to shoulder with our partners, to eradicate any revival of IS and their violent and radical beliefs in the area," Britain's Defence Chief the Defence Secretary stated.
UK warplanes have conducted overwatch operations over Syria to "forestall any attempted comeback" of IS subsequent to its military defeat at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of the UK armed forces participating in this mission for their skill and their bravery," Healey added. "Including them were numerous British troops deployed over Christmas and New Year. This operation, to take out militants who pose a risk to our way of life, demonstrates how our armed forces are always on standby, all year round, keeping Britain secure domestically and strong abroad."
During December, the American forces conducted what it described as a "large-scale strike" targeting Daesh sites in Syria, following an assault claimed the lives of two US troops and a civilian linguist in the Palmyra area.
The U.N. estimates Daesh still has between 5,000 and 7,000 fighters in both countries.